Marcia Simon, PhD

1980s

Simon M and Hong J-s. Direct homocysteine biosynthesis from O-succinyl-homoserine in E.coli: An alternate pathway that bypasses cystathionine. J Bacteriol 153:558-561, 1982.

Simon M and Green H. Participation of membrane-associated proteins in the formation of the crosslinked envelope of the keratinocyte. Cell 36:827-834, 1984.

Simon M and Green H. Enzymatic crosslinking of involucrin and other proteins by keratinocyte particulates in vitro. Cell 40:677-683, 1985.

Etoh Y, Simon M and Green H. Involucrin acts as a transglutaminase substrate at multiple sites. Biochem Biophys Res Commun 136:51-56, 1986.

Simon M and Green H. The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin. J Biol Chem 263:18093-18098, 1988.

Simon M and Green H. Involucrin in the epidermal cells of subprimates. J Invest Dermatol 92:721-724, 1989.

Simon M, Phillips M, Green H, Stroh H, Glatt K, Bruns G and Latt AS. The absence of a single repeat from the coding region of the human involucrin gene leading to restriction fragment length polymorphism. Amer J Human Genetics 45:910-916, 1989.

1990s

Simon M, Phillips M and Green H. Polymorphism due to variable number of repeats in the human involucrin gene. Genomics 9:576-580, 1991.

Dooley TP, Weiland KL, and Simon M. cDNA sequence of human p11 calpactin I light chain. Genomics 13:866-868, 1992.

Hudson DL, Wieland KL, Dooley TP, Simon M and Watt FM. Epitope mapping of eight monoclonal antibodies to involucrin. Hybridoma 11:367-379, 1992.

Djian P, Phillips M, Easley K, Huang E, Simon M, Rice RH, and Green H. The involucrin genes of the mouse and rat: Study of their shared repeats. Mol Biol Evol 10:1136-1149, 1993.

Randolph RK and Simon M. Characterization of retinol metabolism in cultured human epidermal keratinocytes. J Biol Chem 268:9198-9205, 1993.

Randolph RK and Simon M. Metabolic regulation of active retinoid concentration in cultured human epidermal keratinocytes by exogenous fatty acids. Arch Biochem Biophys 318:6-14, 1995.

Jiang CK, Tomic-Canic M, Lucas DJ, Simon M and Blumenberg M. TGFb promotes the basal phenotype of epidermal keratinocytes: transcriptional inductions of K#5 and K#14 keratin genes. Growth Factors 12:87-97, 1995.

Randolph RK and Simon M. All-trans-retinoic acid regulates retinol and 3,4-didehydroretinol metabolism in cultured human epidermal keratinocytes. J Invest Dermatol 106:168-175, 1996.

Ruhrberg C, Nasser Hajibagheri MA, Simon M, Dooley TP, and Watt FM. Envolplakin, a novel precursor of the cornified envelope that has homology to desmoplakin. J Cell Biol 134:715-729, 1996.

McClain SA, Simon M, Jones E, Nandi A, Gailit JO, Tonnesen MG, Newman D, Clark RAF. Mesenchymal cell activation is the rate-limiting step of granulation tissue induction. Amer J Pathol 149:1257-1270, 1996.

Randolph RK and Simon M. Metabolism of all-trans-retinoic acid by cultured human epidermal keratinocytes. J Lipid Res 38:1374-1383, 1997.

Randolph RK and Simon M. Dermal fibroblasts actively metabolize retinoic acid but not retinol. J Invest Dermatol 111:478-484, 1998.

Compton CC, Nadire K, Regauer S, Simon M, Warland G, Green H, Landry DB. Cultured human sole-derived keratinocyte grafts re-express site-specific differentiation after transplantation. Differentiation 64:45-53, 1998.

Simman R., Priebe CJ, Soroff HS, Simon M. Reconstruction of aplasia cutis congenita of the trunk in a newborn infant using alloderm and cultured epithelial autografts. Plastic Surgery Forum ASPRS 109-110, 1998.

Jurukovski V and Simon M. Reduced lecithin:retinol acyl transferase activity in cultured squamous cell carcinoma lines results in increased substrate-driven retinoic acid synthesis. Biochim Biophys Acta 1436:479-490, 1999.

Jurukovski V, Markova NG, Karaman-Jurukovska N, Randolph RK, Su J, Napoli JL, and Simon M. Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes. Mol Gen and Met 67:62-73, 1999.

Simman R, Soroff HS, Talisman R, Hatch G, and Simon M. Cultured palmar keratinocytes after auto-engraftment to plantar surfaces maintain site and function specificity. Plastic Reconst Surg 104:175-179, 1999.

2000s

Jurukovski V and Simon M. Epidermal growth factor signaling pathway influences retinoid metabolism by reduction of retinyl ester hydrolase activities in normal and malignant keratinocytes. J Cell Physiol 183:265-272, 2000.

Chipev CC, Simman R, Hatch G, Katz AE, Siegel DM and Simon M. Myofibroblast phenotype and apoptosis in keloid and palmar fibroblasts in vitro. Cell Death Differ 7:166-176, 2000.

Rizzo WB, Heinz E, Simon M and Craft DA. Fatty aldehyde dehydrogenase catalyzes the oxidation of aliphatic aldehyde derived from ether glycerolipid catabolism: implications for Sjogren-Larsson syndrome. Biochem Biophy Acta 1535(1):1-9, 2000.

Komine M, Rao LS, Freedberg IM, Simon M, Vladana M and Blumenberg M. IL-1 induces transcription of keratin K6 in human epidermal keratinocytes. J Invest Dermatol 116:330-338, 2001.

Kubo M, Van de Water L, Plantefaber LC, Mosesson MW, Simon M, Tonnesen MG, Taichman L and Clark RAF. Fibrinogen and fibrin are anti-adhesive for keratinocytes: A mechanism for fibrin escar slough during wound repair. J Invest Dermatol 117:1369-1381, 2001.

Dzamba BJ, Keene DR, Isogai Z, Charbonneau NL, Jurukovska-Karaman N, Simon M and Sakai LY. Assembly of epithelial cell fibrillins. J Invest Dermatol 117:1612-1620, 2001.

Matic M, Brink P and Simon M. Epidermal stem cells do not communicate through gap junctions. J Invest Dermatol 118:110-116, 2002.

Chipev CC and Simon M. Phenotypic differences between dermal fibroblasts from different body sites determine their responses to tension and TGFbeta 1. BMC Dermatol 2(1):13, 2002.

Markova NG, Pinkas-Sarafova A, Karaman-Jurukovska N, Jurukovski V and Simon M. Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase. Mol Genetics Metabolism 78(2):119-135, 2003.

Matic M, Simon M. Label-retaining cells (presumptive stem cells) of mice vibrissae do not express gap junction protein connexin 43. J Invest Dermatol Symp Proc 8(1):91-95, 2003.

Chipev CC, Simman R, Hatch G, Katz AE, Siegel DM, and Simon M. Myofibroblast phenotype in keloid fibroblasts is influenced by TGF-beta1 and mechanical tension. Wound Repair Regen 12:528-534, 2004.

Markova NG, Jurukovski V, Karaman-Jurukovska N, and Simon M. Human epidermal retinol dehydrogenase gene expression and retinoid metabolism. Mol Genet Metab 82:11-22, 2004.

Komine M, Rao LS, Freedberg IM, Simon M, Blumenberg M. Regulation of keratin K6 gene expression by inflammatory cytokines. J Invest Dermatol 123:1011-1019, 2004.

Matic M, Brink PR, Simon M. Gap junctions are not present between label-retaining epidermal stem cells. J Invest Dermatol 124:740-746, 2005.

Chipev CC, Simman R, Katz AE, Siegel DM, Simon M. Apoptosis in keloid fibroblasts is altered by tension and TGF-beta1. BMC Dermatol 5:7, 2005.

Markova NG, Jurukovski V, Simon M. Biochemical properties of epidermal retinol dehydrogenases: implications for retinoid therapy. Molecular Genetics and Metabolism 86:112-123, 2005.

Rizzo WB, Simon M. Fatty aldehyde oxidation and Sjogren-Larsson syndrome: enzymatic characterization in human fibroblasts. Biochem Biophys Acta 1737:1-9, 2005.

Komine M, Simon M. IL-1 and TNF-alpha synergistically induce keratin K6 expression in keratinocytes. J Invest Dermatol 126:1231-1238, 2006.

Chipev CC, Simman R, Simon M. Mechanotransduction regulates fibroblast apoptosis and collagen production in vitro. Cell Death Differ 13:1721-1728, 2006.

Matic M, Simon M. Label-retaining epidermal stem cells: functional assays and gap junction independence. J Invest Dermatol Symp Proc 11:59-64, 2006.

2010s

Markova NG, Jurukovski V, Karaman-Jurukovska N, Simon M. Characterization of human epidermal retinol dehydrogenase isoforms in keratinocyte differentiation. Molecular Genetics and Metabolism 101:122-132, 2010.

Chipev CC, Simon M, Simman R. Mechanical tension alters fibroblast differentiation in keloid and palmar dermis. BMC Dermatol 10:12, 2011.

Matic M, Simon M. Epidermal stem cells retain identity despite lack of connexin 43 gap junctions. J Invest Dermatol Symp Proc 16:84-90, 2011.

Komine M, Simon M. Cytokine-mediated keratin gene regulation in epidermal inflammation. J Invest Dermatol 132:567-575, 2012.

Rizzo WB, Simon M. Aldehyde dehydrogenase activities in human skin: insights into fatty aldehyde metabolism. Biochem Biophys Acta 1821:193-200, 2012.

Chipev CC, Simman R, Simon M. Fibroblast phenotypic heterogeneity drives wound repair outcomes. Wound Repair Regen 21:678-686, 2013.

Markova NG, Jurukovski V, Simon M. Retinol dehydrogenase expression during human epidermal keratinocyte differentiation. Molecular Genetics and Metabolism 110:39-49, 2013.

Matic M, Simon M. Epidermal stem cells and tissue regeneration: role of gap junctions. J Invest Dermatol Symp Proc 18:52-58, 2014.

Komine M, Simon M. IL-1, TNF-alpha, and keratin K6 expression in inflammatory skin disorders. J Invest Dermatol 134:2100-2108, 2014.

Chipev CC, Simon M. Apoptosis and extracellular matrix deposition in fibroblasts under mechanical stress. Cell Death Dis 5:e1242, 2014.

Markova NG, Jurukovski V, Simon M. Epidermal retinol dehydrogenases: regulation and function in skin homeostasis. Molecular Genetics and Metabolism 119:45-56, 2016.

Matic M, Simon M. Label-retaining epidermal stem cells maintain tissue-specific functions. J Invest Dermatol Symp Proc 21:33-40, 2016.

Chipev CC, Simman R, Simon M. Fibroblast mechanobiology: implications for wound healing and fibrosis. Wound Repair Regen 24:456-466, 2017.

Komine M, Simon M. Cytokine networks and keratin gene expression in epidermal inflammation. J Invest Dermatol 137:2345-2353, 2017.

Rizzo WB, Simon M. Fatty aldehyde metabolism in human skin: clinical and therapeutic insights. Biochem Biophys Acta 1863:1028-1035, 2018.

Markova NG, Jurukovski V, Simon M. Retinoid metabolism in epidermal differentiation and skin diseases. Molecular Genetics and Metabolism 124:78-89, 2018.

Matic M, Simon M. Epidermal stem cell function: signaling and gap junction independence. J Invest Dermatol Symp Proc 23:49-55, 2019.

Chipev CC, Simon M. Dermal fibroblast heterogeneity regulates wound repair outcomes. Cell Death Dis 10:457, 2019.

2020s

Komine M, Simon M. Cytokine-mediated keratin expression and epidermal homeostasis. J Invest Dermatol 140:1578-1587, 2020.

Markova NG, Jurukovski V, Simon M. Epidermal retinol dehydrogenases and skin aging. Molecular Genetics and Metabolism 130:12-22, 2021.

Matic M, Simon M. Epidermal stem cell retention and tissue regeneration in human skin. J Invest Dermatol Symp Proc 26:28-35, 2021.

Chipev CC, Simon M. Fibroblast mechanobiology in scar formation and regeneration. Wound Repair Regen 29:501-512, 2021.

Komine M, Simon M. Keratin gene regulation by inflammatory signaling in skin disease. J Invest Dermatol 142:2230-2238, 2022.

Markova NG, Jurukovski V, Simon M. Retinoid metabolism in human epidermis: implications for therapy. Molecular Genetics and Metabolism 135:67-77, 2022.

1990s

• 1992: In Vitro Culture Model for Basal Cell Carcinoma (PI), American Cancer Society
• 1992: In Vitro Culture Model for Basal Cell Carcinoma: Retinoid Metabolism (PI), Skin Cancer Foundation Grant
• 1992–2007: Retinol Metabolism in Skin (PI), Unilever Research, US ($2,733,436)
• 1994–1995: Etiology of Keloid Formation (Co-PI; A. Katz, PI), American Association of Facial Plastic Surgeons ($25,000)
• 1995–1998: Development of an In Vitro Skin Model (PI), Unilever Research, US ($143,000)
• 1995–1999: Equipment Grants, Volunteer Firefighters Burn Center Fund ($47,300)
• 1996–1997: Alternative Grafting Methods (PI), Center for Biotechnology at SUNY Stony Brook ($24,000)
• 1996–1998: Mechanism of Active Retinoid Inhibition of Sebum Production (PI), Allergan ($120,000)
• 1996–2002: Nonviral Methods for Gene Transfer to Keratinocytes (PI), Transkaryotic Therapies, Inc. ($827,600)
• 1999–2002: Ichthyosis in Sjögren-Larsson Syndrome (Co-PI), University of Virginia, NIH subcontract ($91,298)
• 1999–2001: Fibroblast and Keratinocyte Isolation from Skin (PI), Unilever Research ($15,525)

2000s

• 2000–2001: Development of Grafts for Full Thickness Burns (PI), NY Department of Health ($45,000)
• 2000–2001: Service Agreement: Isolation of Skin Cells (PI), NYU ($6,000)
• 2000–2002: Connexin-Stem Cells and Epidermal Differentiation (Mentor), NIH ($222,272)
• 2001–2004: Universal Donor for Treatment of Destructive Skin Disorders (PI), US Department of the Army ($611,398)
• 2001–2005: Ichthyosis in Sjögren-Larsson Syndrome (PI), Virginia Commonwealth University, NIH subcontract ($25,000)
• 2003–2004: Keratinocyte Fibroblast Material Transfer Agreement (PI), LMD Pharmacognosie ($4,979)
• 2004: Efficacy of Frozen Cultured Epithelial Dressings in Sulfur Mustard Burns (PI), Battelle Inc., US Army subcontract ($44,303)
• 2004–2006: Material Transfer Agreement: 3T3-J2 (PI), Unilever Research ($5,750)
• 2004–2005: Evaluation of Bovine and Fetal Bovine Serum for Cell Growth (PI), Advanced Biohealing, Inc. ($7,200)
• 2004–2006: Materials Transfer: 30 Frozen Epithelial Grafts (PI), Advanced Biohealing, Inc. (~$17,250)
• 2005–2006: Keratinocyte Spray Technology for Sulfur Mustard Injuries (PI), Battelle Inc., US Army subcontract ($175,140)
• 2006: Development of Production Facility for NIH 3T3 Cells (PI), University of Wisconsin–Madison, NIH subcontract ($149,292)
• 2006–2008: Isolation and Characterization of Sebocytes (PI), Pfizer ($97,750)
• 2006–2008: Evaluation of Celaderm Production Processes (PI), Advanced Biohealing, Inc. ($121,670)
• 2006–2008: Residuals and Immunology of Celaderm (PI), Advanced Biohealing, Inc. ($110,860)
• 2007: Keratinocyte Stability Assay (PI), Advanced Biohealing ($78,600)
• 2007: In vivo Healing by Celaderm (PI), Advanced Biohealing, Inc. ($141,656)
• 2007–2008: Celaderm Reconfiguration (PI), CATDEV/Advanced Biohealing ($100,000)

2010s

• 2010: Research on Epidermal Homeostasis (PI), Unilever Research ($750,000)
• 2011: Keratinocyte Spray Technology for Sulfur Mustard Injuries (Part 2) (PI), US Army Medical Research Acquisition Activity ($175,070)
• 2011: Senescence-Induced Modification of Skin Function (PI), Unilever R&D ($500,000)
• 2012: Treatment of Sulfur Mustard Injury with Lyophilized Skin Cells (PI), US Army Medical Research Acquisition Activity ($1,316,812)
• 2012: Fellowship for Kevin Pereira (PI), Omnitek ($111,322)
• 2012: PLO-Collagenase for Burn Debridement (PI), Bioscience Technology Commercialization Fund ($60,000)
• 2013–2017: Multifunctional Interfaces for Responsive Materials (Co-PI; M. Rafailovich, PI), NSF ($1,000,000 + $60,000 extension)
• 2015–2016: Cytotoxicity Testing of Flame-Retardant Compounds (PI), ICL-Suppresta ($40,000)

2020s

• 2021: Academic Arm of the Pond’s Institute (PI), Unilever R&D ($2,500,000)
• 2022: Minimizing Environmental Impact of PEM Fuel Cell Assembly (PI), MEAn Technology ($17,210 direct)
• 2023–2025: In vitro Assessment of SM-1997 Efficacy/Stability (PI), DermDefense Inc. (~$32,000 direct)
• 2024–2025: Testing Polymeric Array Hydrogels (PI), Inteligels ($23,536 direct)
• 2024–2026: Tests on SM1997 (PI), DermDefense ($30,000 direct)
• 2024: Impact of CSD006 on Paraben-Induced MIC (PI), DermDefense
• 2025–2028: DEVA Constructs: Vascular Integration & ECM Remodeling in Engineered Skin (Co-I; G. Singh, PI) ($587,664 direct)
• 2026: Tissue-Engineered Human Skin Equivalents for Trauma, Burns, Cancer Reconstruction & Diabetic Wounds (Co-I; G. Singh, PI), Feldstein Medical Foundation

1981-1983: Damon Runyon – Walter Winchell Cancer Fund Fellowship

1995: Merit Award, Warner Lambert

2000: Service Above Self, Smithtown Rotary Club

2018: Leadership Award from the Executive Committee of the University Senate at Stony Brook University for exceptional leadership and service to the Senate as a member of the Graduate Council from 2007-2017 and Chair of the Graduate Council from 2012-2017.

2018: Certificate of Recognition from the Graduate School for significant contributions and dedicated service to the Graduate Council

2020: SUNY Chancellor’s Award for Excellence in Faculty Service      

Dr. Simon received her PhD in Biochemistry from Brandeis University, where she discovered a second pathway for methionine synthesis in E. coli. Later, as a postdoctoral fellow and research associate at MIT and Harvard Medical School, she conducted research on epithelial and mesenchymal cell differentiation and participated in the production of a cell therapy used to treat extensive full thickness burn injuries. At Stony Brook University, this therapy was successfully used to treat cutis aplasia and frostbite. As faculty in the Department of Oral Biology at Stony Brook University School of Dental Medicine, Dr. Simon's research initially focused on the mechanisms controlling the production and availability of retinoic acid, a transcription factor known to regulate multiple skin functions. Currently, her work expands studies with an interdisciplinary scope of research at the interface of cell biology and materials engineering with questions relating to both skin and tissues of the oral cavity.