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Dr. Lorne Golub


 

Golub

Lorne M. Golub, DMD, MSc, MD (Honorary)
SUNY Distinguished Professor
Department of Oral Biology and Pathology

 

 

 





 

DMD: University of Manitoba (1963)
Fellowship/Advanced Training: Fellowship-Certification in Periodontics, Harvard School of Dental Medicine (1968); MSc, University of Manitoba (1965)
Additional: Honorary MD, Faculty of Medicine, University of Helsinki (2000)
Research Interests: Dr. Golub’s research focuses on mechanisms of collagen degradation including bone resorption during periodontal disease (and relevant medical disorders) particularly the role of tissue (“Host”)-derived matrix metalloproteinases, such as the collagenases (e.g., MMP-8) and gelatinases (e.g., MMP-9).  In this regard, he was the 1st to develop government (USA, Canada, Europe)-approved MMP-inhibitor drugs for any disease, but particularly for periodontitis and the chronic inflammatory skin disease, rosacea.  The same medications have also demonstrated clinical efficacy, and safety, in humans with other inflammatory-collagenolytic diseases such as arthritis, diabetes, cardiovascular disease, and cancer.  The 1st generation medications are novel NON-antibiotic regimens of tetracyclines which function, at least in part, by binding calcium & zinc in the catalytic domain of these neutral proteinases.  Second-generation medications being developed are bi-phenolic rather than tetra-phenolic, with a similar (even enhanced) cation-binding site, and are derived from novel chemical modifications of the natural spice curcumin.  His research includes (but is not limited to) cell and tissue culture, in vivo studies using different animal models, and clinical trials.

Honors and Awards:

Editorial Boards: J. Dent. Res. (1977), J. Periodont.Res. (1984) and J. Periodontol. (1990).

(2017) Fellow of the National Academy of Inventors, Boston

NIH Merit Award (10 years funding 1988-98); University of Helsinki Rector's Medal (1991); Annual Birnberg Research Award, Columbia University (1996); Annual Distinguished Scientist Award in Oral Biology, IADR (1998); Ramfjord Memorial Lectureship, Univ. Michigan (1999); Faculty of Medicine, University Helsinki "Doctor Honoris Causa" (2000); Annual 'ADA Norton M. Ross Award for Excellence in Clinical Research (2001); Distinguished Alumnus Award University of Manitoba (Canada, 2002); "Outstanding Inventors Award", Research Foundation of SUNY (2002); promoted by the Board of Trustees, SUNY, to the rank of Distinguished Professor (2003); ADA Gold Medal for Excellence in Research (2006); Research highlighted in "Technology Transfer Stories- 25 Innovations that changed the world", Association University Technology Managers; DistinguishedFaculty Member, Center for Biotechnology (NYSTAR Center for Advanced Technology (2009); Invited to be guest editor of two special issues, Pharmacological Research, Elsevier Publishers, (2011); Research paper highlighted as Cover Story, JADA March (2011). Inducted member of Stony Brook University National Academy of Inventors (2016).

Publications and Patents:Over 300 peer-reviewed papers and monographs published in various dental, medical and biological journals, and over 35 patents issued.
Language(s) spoken: English
Consultations & Appointments: 631-632-8912
Email Address: Lorne.Golub@stonybrookmedicine.edu
 

JADA

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