Ying Gu, DDS, MS, PhD

Peer-Reviewed Journals

Gu, Y., Lee, H.M., Roemer, E.J., Musacchia, L., Golub, L.M., and Simon, S.R. Inhibition of tumor cell invasiveness by chemically modified tetracycline. Curr. Med. Chem. 8:261-270, 2001

Gu, Y., Lee, H.M., Sorsa, T., Golub, L.M., and Simon, S.R. Inhibition of breast cancer cell by chemically modified tetracycline. Ann. Med. 37:450-460, 2005

Gu, Y., Lee, H.M., Simon, S.R., and Golub, L.M. Doxycycline inhibits mononuclear cell mediated connective tissue breakdown. FEMS Immunol. Med. Microbiol. 58: 218–225, 2010, Epub 2009.

Gu, Y., Lee, H.M., Simon, S.R., and Golub, L.M. Chemically modified tetracycline-3 (CMT-3): A novel inhibitor of the serine proteinase, elastase. Pharmacol. Res. 64(6):595-601, 2011.

Gu, Y., Lee, H.M., Sorsa, T., Salminen, A., Ryan, M., Slepian, M., and Golub, L.M. Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: A mechanistic link between local and systemic inflammation. Pharmacol. Res. 64(6):573-9, 2011.

Carrion, J., Scisci, E., Miles, B., Sabino, G., Zeituni, A., Gu, Y., Bear, A., Genco, C., Brown, D., and Cutler, C. Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential. J. Immunol. 189:3178-3187, 2012.

Gu, Y., Walker, C., Ryan, M., Payne, J., and Golub, L.M. Non-antibacterial tetracycline formulations: Clinical applications in dentistry and medicine. J. Oral Microbiol. 4. doi: 10.3402/jom.v4i0.19227, 2012.

Zhang, Y., Gu, Y., Lee, H.M., Hambarjieva, E., Vrankova, V., Golub, L.M., and Johnson, F. Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases. Curr Med Chem. 19(25): 4348-4358, 2012.

Gu, Y., Lee, H.M., Napolitano, N., Clemens, M., Sorsa, T., Zhang, Y., Zhang, Y., Johnson, F., and Golub, L.M. 4-methoxycarbonyl curcumin: a novel inhibitor of inflammatory mediators for periodontitis and other diseases. Mediators of Inflammation doi:10.1155/2013/329740, 2013.

Jones, J.A., Golub, L.M., Gu, Y., Ryan, M.E., Masse, D., and Simard, J. Is Periodontitis an Infectious or an Inflammatory Disease? Oral Hygiene, p.16-30, 2015.

Hou, J., Gu, Y., Hou, W., Wu, S., Lou, Y., Yang, W., Zhu, L., Hu, Y., Sun, M., and Xue, H. P53 codon 72 polymorphism, human papillomavirus infection, and their interaction to oral carcinoma susceptibility. BMC Genet. 16:72, 2015.

Hou, J., Gu, Y., Zhu, L., Hu, Y., Sun, M., and Xue, H. Systemic review of the prevention of pit and fissure caries of permanent molars by resin sealants in children in China. J Investig Clin Dent. doi: 10.1111/jicd.12183, 2015.

Donley, T., Jones, J.J., Golub, L.M., Gu, Y., and Ryan, M.E. Addressing the inflammatory response in periodontal and systemic diseases. Oral Health, October 1, 2015.

Golub, L.M., Elburki, M.S., Sorsa, T., Tenenbaum, H., Ryan, M., Wolff, M., Walker, C., and Gu, Y. NON-Antibacterial Tetracycline Formulations: Host-Modulators in the Treatment of the Periodontal Patient, and Systemic Implications. Int Dent J. 66(3):127-35, 2016.

Zhang, Y., McClain, S.A., Lee, H.M., Elburki, M.S., Yu, H., Gu, Y., Zhang, Y., Wolff, M., Johnson, F., and Golub, L.M. A Novel Chemically Modified Curcumin "Normalizes" Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies. J Diabetes Res. 2016:5782904, 2016.

Golub, L.M., Gu, Y., Tenenbaum, H., and Sorsa, T. A “point-by-point” Statement on Periodontal Host-Modulation Therapy: SAFETY FIRST! Oral Health, July 3, 2018.

Wang, H., Lee, H.M., Raja, V., Iacono, V.J., Scaduto, J., Johnson, F., Golub, L.M., and Gu, Y. Enhanced Efficacy of Chemically Modified Curcumin in Experimental Periodontitis: Systemic Implications. J. Exp Pharmacol. 11:1-14, 2019.

Gu, Y., Foo, P., Guo, A., Giordano, A., Walker, S., and Chiang, F. Laser Diffractometer for Measuring Bacterial Biodegradation of Dental Materials. Mechanics of Biological Systems and Materials & Micro-and Nanomechanics. 4:87-92, 2019.

Deng, J., Golub, L.M., Lee, H.M., Lin, M., Bhatt, H., Hong, H., Johnson, F., Scaduto, J., Zimmerman, T., and Gu, Y. Chemically-Modified Curcumin 2.24: A Novel Systemic Therapy for Natural Periodontitis in Dogs. J. Exp Pharmacol. 12:47-60, 2020.

Gu, Y., Hou, W., Lee, H.M., Golub, L.M., and Ryan, M.E. Periodontal Disease in Acute Coronary Syndrome Patients: A Pilot Study. Am J Dent. 34(2):97-100, 2021.

Gu, Y., Raja, V., Lee, H.M., Prestwich, G., and Ryan, M.E. Therapeutic Potential of a Novel Semi-Synthetic-Sulfated-Polysaccharide to Suppress Inflammatory Mediators in P. gingivalis LPS stimulated human monocytes/macrophages. J Inflamm 18:26, 2021.

Deng, J., Golub, L.M., Lee, H.M., Bhatt, H., Hong, H., Johnson, F., Scaduto, J., Zimmerman, T., and Gu, Y. A Novel Chemically-Modified Curcumin 2.24: Short-term Systemic Treatment for Natural Periodontitis in Dogs. Front. Dent. Med. 2:609795, 2021.

Shang, C., Feng, L., Gu, Y., Hong, H., Hong, L., and Hou, J. Impact of Multidisciplinary Team Management on the Survival Rate in Head and Neck Cancer Patients: a Meta-analysis of Cohort Studies. Front. Oncol. 11:630906, 2021.

Deng, J., Golub, L.M., Lee, H.M., Raja, V., Johnson, F., Kucine, A., Lee, W., Xu, T.M., and Gu, Y. Novel Modified-Curcumin Promotes Resolvin-like Activity and Reduces Diabetes-induced Bone Loss. J Inflamm Res. 14:5337–5347, 2021.

Bhatt, H., McClain, S., Lee, H.M., Zimmerman, T., Deng, J., Johnson, F., Gu, Y., and Golub, L.M. The Maximum-Tolerated Dose and Pharmacokinetics of a Novel Chemically-Modified-Curcumin in Rats. J Exp Pharmacol. 14:73-85, 2022.

Raja, V., Gu, Y., Lee, H.M., Deng, J., Prestwich, G., and Ryan, M.E. SAGE: Novel therapy to reduce inflammation in a naturally-occurring-dog model of periodontal disease. J Exp Pharmacol. 14:117-129, 2022.

Bhatt, H., Golub, L.M., Lee, H.M., Kim, J., Zimmerman, T., Deng, J., Hong, H., Johnson, F., and Gu, Y. Efficacy of a Novel Pleiotropic MMP-Inhibitor, CMC2.24, in a Long-term Diabetes Rat Model with a Severe Hyperglycemic-induced Oral Bone Loss. J Inflamm Res. 16:779–792, 2023.

Deng, J., Golub, L.M., Lee, H.M., Bhatt, H., Johnson, F., Xu, T.M., and Gu, Y. A novel modified-curcumin 2.24 resolves inflammation by promoting M2 macrophage polarization. Sci Rep 13:15513, 2023.

Bacigalupo, J., Golub, L.M., Sorsa, T., Lee, H.M., Gu, Y., and Walker, S.G. Managing Tissue Health Around Natural Teeth And Dental Implants: A Clinician’s Experience. J Comm Med and Pub Health Rep 5(01), 2024.

Golub, L.M., Lee, H.M., Bacigalupo, J., and Gu, Y. Host Modulation Therapy in Periodontitis Diagnosis and Treatment - Status update. Front. Dent. Med 5:1423401, 2024.

Dai, Q., Lee, H.M., Giordano, A., Chiang, F.P., Walker, S.G., Delgado-Ruiz, R., Johnson, F., Golub, L.M., and Gu, Y. Effect of a chemically-modified-curcumin on dental resin biodegradation. Front. Oral Health 5:1506616, 2025.

Dai, Q., Davis, R., Hong, H., and Gu, Y. A Comparative Pilot Study of Computer-Based Evaluation Software vs. Traditional Evaluation in Preclinical Operative Procedures. J. Dent. Ed. 89(9):1395-1402, 2025.

Gu, Y., Golub, L.M., Lee, H.M., and Walker, S.G. Diabetes, Periodontal Disease, and Novel Therapeutic Approaches- Host Modulation Therapy. Front. Clin. Diabetes Healthc. 6:1529086, 2025.

Book Chapters

Gu, Y., and Ryan, M.E. Overview of periodontal diseases: causes, pathogenesis, and characteristics.” In Williams, R., and Genco, R. (Eds): Periodontal Diseases and Overall Health: A Clinician’s Guide, 1st edition: 5-23, 2009, Professional Audience Communications, Inc. Yardley, PA

Ryan, M.E., and Gu, Y. “Host Modulation.” In Newman, M., Takei, H., Klokkevold, P., and Carranza, F. (Eds): Clinical Periodontology, 11th edition: 492-502, 2009, Elsevier Saunders, Philadelphia, PA

Gu, Y., Loos, B.G., and Ryan, M.E. Overview of periodontal diseases: causes, pathogenesis, and characteristics.” In Williams, R., and Genco, R. (Eds): Periodontal Diseases and Overall Health: A Clinician’s Guide, 2nd edition, 2014, Professional Audience Communications, Inc. Yardley, PA

Ryan, M.E., and Gu, Y. “Host Modulation.” In Newman, M., Takei, H., Klokkevold, P., and Carranza, F. (Eds): Clinical Periodontology, 12th edition, 2014, Elsevier Saunders, Philadelphia, PA

Ryan, M.E., and Gu, Y. “Host Modulation.” In Newman, M., Takei, H., Klokkevold, P., and Carranza, F. (Eds): Clinical Periodontology, 13th edition, 2018, Elsevier Saunders, Philadelphia, PA

Ryan, M.E., and Gu, Y. “Host Modulation.” In Newman, M., and Carranza, F. (Eds): Clinical Periodontology and Implantology, 14th edition, 2023, Elsevier Saunders, Philadelphia, PA

2025 – present: SBU OVPR Seed grant – $60,000

“Early Diagnosis of Periodontal Disease using Multimodal Imaging"

Role: mPI

2016 – 2021: NIH/STTR phase II – $1.3 Million

“Pre-Clinical Safety and Efficacy of TRB-N0224 for the Treatment of Periodontal Disease”

Role: mPI

2015 – 2016: NIH/STTR phase I R4  – $192,000

“Evaluation of TRB-N0224, a Proprietary Chemically Modified Curcumin, for the Treatment of Periodontal Disease in a LPS-Induced Rat Model.”

Role: mPI

2013 – 2017: SBIR/NIH phase II – $1.5 Million

“Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis.” 

Role: Co-PI 

2011 – 2013: SBIR/NIH phase I – $210,000

“Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis.” 

Role: Co-PI 

2009 – 2011: NIH SBM General Clinical Research Center – $10,000

“Evaluation of Oral Inflammatory Burden on Acute Coronary Syndrome Patients.” 

Role: Co-PI

2000 – 2003: NIDCR/NIH F30 – $85,834

“Individual Predoctoral Dental Scientist Fellowship.”

Role: PI

2024: Inducted to American College of Dentists

2024: Inducted to Omicron Kappa Upsilon national dental honor society

2023 – 2024: Individual Development Award, NY State/United University Professions

2014 – 2015: Faculty Development Award, Office of Research, School of Dental Medicine

2013: Sydney & Edith Golub Endowed Faculty Development Award

2010: Professional Development Award, NY State/United University Professions

2002: The Quintessence Award in Recognition of Academic Achievement

2001: Gwinnett Memorial Dental Student Award

1998: Sigma XI Scientific Research Society, Excellence in Research Award 

1998: Society for In Vitro Biology, Excellence in Research in Cellular Toxicology 

Dr. Ying Gu is a professor and chair of the Department of General Dentistry at Stony Brook School of Dental Medicine. She received her DDS and PhD degrees and completed her AEDG training from Stony Brook University. Dr. Gu has over 20 years of experience in teaching, practice and research. Her teaching interests and responsibilities include clinical comprehensive care and the biology of supporting structures in dental medicine. Her research has been funded by the NIH as well as industry and university sources, totaling over $15 million, focuses on the mechanisms underlying the oral-systemic connection and developing new therapeutics. An active member of the American Association for Dental, Oral, and Craniofacial Research (AADOCR), the International Association for Dental Research (IADR), and the American Dental Education Association (ADEA), Dr. Gu has previously served as president of the AADOCR-LI Section, councilor of AADOCR, and section chair and House of Delegates member in ADEA. She is a fellow of the American College of Dentists and a member of Omicron Kappa Upsilon.